Table 3.
Genomic Fusions in ROS1 Spitz Neoplasms
| Case | Fusion | Copy Number Variation |
|---|---|---|
| 1 | PWWP2A-ROS1 | None identified |
| 2 | TPM3-ROS1 | Copy loss: BCL11B, CARD11, FBXO11, FGF3, FLT4, GRIN2A, HGF, MGMT, MYCN, MYOD1, NPM1, NTRK3, PLAG1, PTPRT, RET, TERT, TLX1 |
| 3 | TPM3-ROS1 | None identified |
| 4 | MYH9-ROS1 | None identified |
| 5 | PPFIBP1-ROS1 | None identified |
| 6 | MYO5A-ROS1 | Copy gain: HOXA9, JUN, MDM2 |
| 7 | TPM3-ROS1 | None identified |
| 8 | Identified by FISH Breakapart Probe | None identified |
| 9 | PWWP2A-ROS1 | None identified |
| 10 | PWWP2A-ROS1 | Copy loss: 6q.22.1* |
| 11 | PWWP2A-ROS1 | None identified |
| 12 | PPFIBP1-ROS1 | None identified |
| 13 | PWWP2A-ROS1 | None identified |
| 14 | TPM3-ROS1 | None identified |
| 15 | TPM3-ROS1 | None identified |
| 16 | CAPRIN1-ROS1 | Not assessed |
| 17 | PWWP2A-ROS1 | None identified |
*
Identified by SNP array