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a) MYPT1 O-GlcNAcylation inhibits its phosphorylation by ROCK1/2. This maintains MYPT1 phosphatase activity, resulting in inactive MLC and no actin contraction. Loss of O-GlcNAc enables ROCK1/2 to phosphorylate and deactivate MYTP1. b) Therefore, MYPT1 O-GlcNAcylation levels control the sensitivity of cells to the concentration of S1P, where more MYTP1 O-GlcNAcylation requires more S1P to illicit actin contraction and cell detachment.
