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Mechanism of MYCi efficacy. MYCi directly binds to MYC, induces phosphorylation of threonine 58 leading to MYC degradation. MYCi inhibits MYC/MAX heterodimerization, blocking MYC-dependent transcription and proliferation. Following MYCi treatment, the tumor microenvironment is altered by infiltration of diverse immune effector cells and increased PD-L1 expression. Combination of MYCi with anti-PD-1/PD-L1 therapy results in improved efficacy.
