Fig. 7.

Effect on liver metabolic parameters in obese WT and P2rx7 KO mice. Male WT and P2rx7 KO mice were kept on a HFD for 16 weeks. a, b Liver weight was determined in P2rx7 KO mice compared with WT controls on the a BALB/c and b C57BL/6 backgrounds. Liver c triglyceride (TG) and d cholesterol levels were determined and normalized to protein concentration. e, f Gene expression of inflammatory markers in the liver of WT and P2rx7 KO mice on the e BALB/c and f C57BL/6 background. n = 5–10 mice per group. Data are presented as mean ± SEM, *P < 0.05