Figure 1. Multivariable-adjusted hazard ratio of esophageal adenocarcinoma and gastric adenocarcinoma across history of periodontal disease and tooth loss.
Cox proportional hazards models were stratified by age (continuous, month), cohort (NHS, HPFS), and study period (in 2-year intervals) and adjusted for the same covariates as the full model in Table 1. P for interaction between periodontal disease and tooth loss was calculated by including a cross-product interaction term between periodontal disease and tooth loss in the model and estimating the significance using the likelihood ratio test.