Extended Data Table 1. Distribution of SARS-CoV2 antigen in Brain.
4 brains were analyzed at 6dpi. + <++<+++ Represents Relative density of antigen presence. - No antigen detected. (+) Represents presence of antigen in some samples only. AON-Anterior Olfactory Nucleus.
Neuroanatomical Reference: ALLEN Brain Atlas. http://atlas.brain-map.org/atlas?atlas=2#atlas=2&plate=100883770&structure=168&x=7797.5&y=4023.9999997615814&zoom=−3&resolution=10.47&z=5.
| Olfactory Bulb | Thalamus | ||
|---|---|---|---|
| Main Olfactory Bulb | Ventral Posterolateral Nucleus | +++ | |
| Glomerular Layer | − | Ventral Posteromedial Nucleus | +++ |
| Granule Layer | − | Ventral Medial Nucleus | ++ |
| Inner Plexiform Layer | − | Ventral Anterior-Lateral Complex | +++ |
| Mitral Layer | + | Anterior group of the Dorsal Thalamus | +++ |
| Outer Plexiform Layer | − | Medial group of the Dorsal Thalamus | +++ |
| Midline group of the Dorsal Thalamus | +++ | ||
| Accessory Olfactory Bulb | Reticular Nucleus | +++ | |
| Glomerular Layer | − | Geniculate Group | +++ |
| Granular Layer | − | ||
| Mitral Layer | ++ | Hypothalamus | +++ |
| Supraoptic Nucleus | +++ | ||
| AON Dorsal | +++ | Paraventricular Nucleus | +++ |
| AON Medial | ++ | Arcuate Nucleus | +++ |
| AON lateral | ++ | Suprachiasmatic Nucleus | +++ |
| Taenia Tecta | + | Subfornical Organ | +++ |
| Anterior Nucleus | +++ | ||
| Premammillary Nucleus | +++ | ||
| Midbrain | Hind Brain | ||
| Superior Colliculus | ++ | Pons | |
| Inferior Colliculus | ++ | Nucleus of Lateral Lemniscus | ++ |
| Nucleus Brachium | ++ | Trigeminal Nucleus | ++ |
| Nucleus Sagulum | ++ | Parabrachial Nucleus | ++ |
| Para Bigeminal Nucleus | ++ | Dorsal Tegmental Nucleus | ++ |
| Midbrain Trigeminal Nucleus | ++ | Pontine Nuclei | ++ |
| Substantia Nigra | +++ | Supratrigeminal Nucleus | ++ |
| Ventral Tegmental Area | ++ | Superior Central Nucleus Raphe | ++ |
| Reticular Nucleus | +++ | Locus Ceruleus | ++ |
| Cuneiform Nucleus | ++ | Laterodorsal Tegmental Nucleus | ++ |
| Red Nucleus | ++ | ||
| Oculomotor Nucleus III | ++ | Medulla | |
| Edinger-Westphal Nucleus | ++ | Area Postrema | +++ |
| Trochlear Nucleus IV | ++ | Cochlear Nuclei | ++ |
| Ventral Tegmental Nucleus | ++ | Dorsal Column Nuclei | ++ |
| Pedunculopontine Nucleus | ++ | External Cuneate Nucleus | + |
| Nucleus Ambiguus | ++ | ||
| Solitary Tract Nucleus | ++ | ||
| Lateral Reticular Nucleus | ++ | ||
| Magnocellular Reticular Nucleus | ++ | ||
| Medullary Reticular Nucleus | ++ | ||
| Parvicellular Reticular Nucleus | ++ | ||
| Nucleus X | ++ | ||
| Hypoglossal Nucleus XII | ++ | ||
| Hippocampus | (+) | ||
| Cerebellum | − |