Table 1.

In vitro stability of nucleotides MRS2365, MRS2179, and MRS2500 in phosphate-buffered saline, astrocyte culture media or mouse, and human astrocyte cell culture

	Media
	PBS, pH 7.4		Astrocyte culture media		Mouse astrocyte cell culture		Human astrocyte cell culture
Compound	T1/2 (min)	% remaining (240 min)	T1/2 (min)	% remaining (240 min)	T1/2 (min)	% remaining (240 min)	T1/2 (min)	% remaining (240 min)
MRS2365	> 240	100%	42	2.5%	25	< 1%	26	< 1%
MRS2179	> 60	100%	-	-	-	-	-	-
MRS2500	> 60	100%	-	-	-	-	-	-

Results are the mean values of 3 replicates per incubation conducted at 37 °C

-Not tested