Table 1.
Patient Characteristics
| Characteristic | All Patients | PSPT Group | IMPT Group | P Value |
|---|---|---|---|---|
| Sex | 0.88 | |||
| Female | 64 (46) | 40 (47) | 24 (45) | |
| Male | 75 (54) | 46 (53) | 29 (55) | |
| Age, median, years | 68 (39–83) | 67 (39–80) | 70 (43–83) | 0.06 |
| Age group, No. (%) | ||||
| <70 | 79 (57) | 54 (63) | 25 (48) | 0.09 |
| ≥70 | 59 (43) | 32 (37) | 27 (52) | |
| Smoking history, No. (%) | ||||
| Never | 12 (9) | 5 (6) | 7 (13) | 0.13 |
| Ever | 127 (91) | 81 (94) | 46 (87) | |
| Tumor histology, No. (%) | ||||
| Adenocarcinoma | 73 (53) | 45 (52) | 28 (53) | 0.84 |
| Squamous cell carcinoma | 43 (31) | 26 (30) | 17 (32) | |
| NSCLC, unspecified | 19 (14) | 12 (14) | 7 (13) | |
| Large cell | 2 (1) | 2 (3) | 0 (0) | |
| Other | 2 (1) | 1 (1) | 1 (2) | |
| Disease stage, No. (%) | 0.52 | |||
| II | 16 (12) | 10 (12) | 6 (11) | |
| IIIA | 55 (40) | 33 (38) | 22 (42) | |
| IIIB | 63 (45) | 38 (44) | 25 (47) | |
| IV | 3 (2) | 3 (3) | 0 (0) | |
| Recurrent | 2 (1) | 2 (2) | 0 (0) | |
| Nodal status, No. (%) | 0.42 | |||
| N0 | 9 (7) | 4 (5) | 5 (9) | |
| N1 | 16 (12) | 12 (14) | 4 (8) | |
| N2 | 64 (46) | 42 (49) | 22 (42) | |
| N3 | 41 (30) | 24 (28) | 17 (32) | |
| Nx | 9 (6) | 4 (5) | 5 (9) | |
| Tumor Location, No. (%) | 0.35 | |||
| RUL | 48 (35) | 30 (35) | 18 (34) | |
| RML | 10 (7) | 3 (4) | 7 (13) | |
| RLL | 17 (12) | 12 (14) | 5 (9) | |
| LUL | 32 (23) | 20 (23) | 12 (23) | |
| LLL | 18 (13) | 13 (15) | 5 (9) | |
| Mediastinum only | 13 (9) | 7 (8) | 6 (11) | |
| Adaptive Planning, No. (%) | 0.90 | |||
| Yes | 28 (20) | 18 (21) | 10 (19) | |
| No | 111 (80) | 68 (79) | 43 (81) | |
| Induction Chemotherapy, No. (%) | 0.004 | |||
| Yes | 55 (40) | 42 (49) | 13 (25) | |
| No | 84 (60) | 44 (51) | 40 (75) | |
| iGTV, cm3, mean (SD) | 140 (143) | 139 (148) | 141 (136) | 0.99 |
| Radiation dose, No. (%) | 0.02 | |||
| <66 Gy(RBE) | 18 (13) | 12 (14) | 6 (11) | |
| 66–68 Gy(RBE) | 39 (28) | 17 (20) | 22 (42) | |
| 68–78 Gy(RBE) | 82 (59) | 57 (66) | 25 (47) | |
| Radiation dose, median (range) | 70 (54–78) | 74 (54–75) | 67 (59–78) | 0.03 |
Abbreviations: iGTV, internal gross tumor volume; SD, standard deviation; RUL, right upper lube; RML, right middle lobe; RLL, right lower lobe; LUL, left upper lobe; LLL, left lower lobe.