Table 3.
Proteins | BMS-754807 + Metformin vs. BMS-754807 | BMS- 754807 + Metformin vs. Metformin | ||
---|---|---|---|---|
p value | Fold Change | p value | Fold Change | |
p27/KIP1 | <0.0001 | 2.60 | <0.0001 | 13.81 |
p-p27(T187) | <0.0001 | 2.27 | <0.0001 | 5.11 |
KLF4 | 0.0010 | 1.71 | <0.0001 | 2.32 |
c-Jun | 0.0145 | 1.60 | <0.0001 | 2.65 |
p-c-Jun(S63) | 0.0001 | 1.53 | <0.0001 | 2.73 |
Cleaved caspase-7 | <0.0001 | 1.45 | <0.0001 | 1.52 |
RRM2 | <0.0001 | −3.94 | <0.0001 | −6.05 |
Ki-67 | <0.0001 | −3.31 | <0.0001 | −8.22 |
Slug | <0.0001 | −2.43 | <0.0001 | −3.51 |
Aurora A | <0.0001 | −2.13 | <0.0001 | −4.56 |
p-Rb(S807/811) | <0.0001 | −1.91 | <0.0001 | −4.73 |
CHAF1A | 0.0122 | −1.88 | <0.0001 | −9.76 |
p-Rb(S780) | <0.0001 | −1.87 | <0.0001 | −4.16 |
HexokinaseII | <0.0001 | −1.82 | <0.0001 | −1.84 |
BRCA1 | <0.0001 | −1.70 | <0.0001 | −3.28 |
Caveolin-1 | 0.0353 | −1.65 | <0.0001 | −2.76 |
HIF-1a | 0.0087 | −1.49 | 0.0246 | −1.49 |
LRP6 | 0.0101 | −1.46 | 0.0002 | −1.80 |
PIAS1 | 0.0211 | −1.44 | <0.0001 | −2.81 |
p-Src(Y527) | 0.0054 | −1.43 | <0.0001 | −3.33 |
ATM | 0.0002 | −1.42 | <0.0001 | −2.06 |
p-EGFR(Y1068) | 0.0117 | −1.38 | <0.0001 | −1.98 |
p-SHC(Y317) | 0.0032 | −1.36 | <0.0001 | −1.70 |
Ezh2 | 0.0351 | −1.32 | <0.0001 | −2.07 |
p-ALK(Y1604) | 0.0370 | −1.30 | <0.0001 | −2.06 |
p-FAK(Y576/577) | <0.0001 | −1.29 | 0.0006 | −1.24 |
STAT3 | 0.0008 | −1.28 | 0.0012 | −1.26 |
Notch1 | 0.0151 | −1.26 | <0.0001 | −1.63 |
p-Beta-Catenin(S33/37/T41) | 0.0069 | −1.25 | <0.0001 | −1.49 |
ILK1 | 0.0015 | −1.23 | <0.0001 | −1.42 |
STAT1 | 0.0042 | −1.21 | <0.0001 | −1.43 |
c-Myc | 0.0352 | −1.21 | <0.0001 | −1.63 |
p-c-Myc(T58) | 0.0396 | −1.21 | <0.0001 | −2.21 |
Rb | 0.0287 | −1.17 | <0.0001 | −3.51 |
SCD1 | 0.0410 | −1.17 | 0.0041 | −1.26 |
The normalized data were log2 transformed for hypothesis testing. For each sample, the median value of three technical replicates was used for statistical analysis. Two-way ANOVA was used to test main effects of the different treatments and their interactions. p value < 0.05 was considered statistically significant.