Table 4-.
Saliva concentrations of selected cytokines at baseline.
| Saliva pg/mL | Control Median (25%-75%) |
NG+GP Median (25%-75%) |
PD+GP Median (25%-75%) |
T2DM+GP Median (25%-75%) |
p-value* |
|---|---|---|---|---|---|
| IL-1β | 23.08 (8.75; 38.5) A | 92.63 (46.12; 159) B | 125 (51.7; 209.2) B | 90.3 (48.7; 141.9) B | <0.01 |
| IL-2 | 6.8 (2.9; 8.4) A | 10.8 (6.36; 35.3) A | 11.9 (9.3; 17.9) A | 8.2 (4.3; 14.8) A | 0.19 |
| IL-6 | 8.15 (4; 16.07) A | 12.7 (8.8; 37.3) A | 14.8 (6.7; 28.8) A | 11.05 (6.05; 14.9) A | 0.26 |
| IL-8 | 1504.6 (455.5; 2217.2) A | 2092 (766.2; 3835.2) A | 3527.5 (1083.2; 10630.1) A | 3615.4 (1046.8; 13517.4) A | 0.15 |
| IL-5 | 0.7 (0.43; 1.38) A | 1.65 (0.55; 18.2) A | 1.92 (1.03; 2.4) A | 0.49 (0.3; 1.9) A | 0.03 |
| IL-4 | 3.27 (2.37; 4.53) A | 5.9 (4.5; 62.8) AB | 8.2 (6.3; 15.8) B | 6.8 (1.5; 12.06) AB | 0.02 |
| IL-10 | 1.34 (0.99; 3.88) A | 3.13 (1.83; 21.5) A | 4.15 (2.27; 6.78) A | 4.95 (0.8; 11) A | 0.28 |
| IFN-γ | 0.34 (0.01; 1.14) A | 0.3 (0.01; 6.9) A | 0.6 (0.3; 1.05) A | 0.11 (0.01; 0.75) A | 0.53 |
| GM-CSF | 3.46 (0.96; 7.26) A | 4.78 (2.9; 17) A | 6.26 (2.7; 12.8) A | 2.38 (1.44; 12) A | 0.62 |
| TNF-α | 6.6 (2.4; 8.3) A | 11.5 (7.3; 50) B | 14 (8.3; 23.1) B | 10.5 (3.9; 18.4) B | 0.01 |
*
Different letters denote statistically different groups (Kruskall Wallis followed by Dunn test with Bonferroni correction).
NG, normoglycemic; PD, pre-diabetes; T2DM, type 2 diabetes mellitus; GP, generalized periodontitis.