Skip to main content
. Author manuscript; available in PMC: 2021 May 9.
Published in final edited form as: Nat Struct Mol Biol. 2020 Nov 9;28(1):50–61. doi: 10.1038/s41594-020-00522-0

Extended Data Fig. 4. Map and model features of the Mec1-Ddc2 complex.

Extended Data Fig. 4

(a) 2D classes of Mec1-Ddc2 after a focused 3D refinement masking on Mec1-Ddc2 heterodimer, showing intrinsic flexibility of the complex across the dimer interface.

(b) Electron density features of the bound AMP-PNP, and (c) strong electron density (unsharpened map) showing the PRD-I interaction with the activation loop at two points (asterisked).

(d) Map to model FSC curves.