Table 1.
Demographics by Aβ Status and Total Sample
| Aβ(+) (n=39) | Aβ(−) (n=63) | Total (n=102) | p | |
|---|---|---|---|---|
| Average Age (SD) | 79.28 (6.40) | 75.90 (5.90) | 77.20 (6.29) | 0.008a |
| Female Sex, n(%) | 22 (56.4) | 34 (54.0) | 56 (54.9) | 0.810b |
| White, n(%) | 36 (92.3) | 59 (93.7) | 95 (93.1) | 1.000c |
| HS Education, n(%) | 20 (51.3) | 20 (31.7) | 40 (39.2) | 0.050 |
| >HS Education, n(%) | 19 (48.7) | 43 (68.3) | 62 (60.8) | |
| APOE*4 Carrier^, n(%) | 11 (28.2) | 3 (4.8) | 14 (13.7) | <0.001c |
| Average Global Aβ (SD) | 1.59 (0.36) | 1.10 (0.05) | 1.29 (0.33) | <0.001a |
| Average Braak 1 Tau (SD) | 1.21 (0.16) | 1.10 (0.12) | 1.14(0.14) | 0.001a |
| Average Braak 3_4 Tau (SD) | 1.15 (0.07) | 1.11 (0.07) | 1.13 (0.07) | 0.005a |
| Average Braak 5_6 Tau (SD) | 1.08 (0.08) | 1.04 (0.07) | 1.05 (0.08) | 0.020a |
| Average MMSE (SD) | 27.67 (2.29) | 28.19 (1.33) | 27.99 (1.77) | 0.199a |
| CDR=0.5, n(%) | 6 (15.4) | 2 (3.2) | 8 (7.8) | 0.051c |
| Subjective Memory Score >0, n (%) | 19 (48.7) | 30 (47.6) | 49 (48.0) | 0.914b |
| Current Hypertension, n(%) | 24 (61.5) | 43 (68.3) | 67 (65.7) | 0.488b |
| Current Diabetes, n(%) | 8 (20.5) | 12 (19.0) | 20 (19.6) | 0.856b |
| Previous TIA, n(%) | 5 (12.8) | 4 (6.3) | 9 (8.8) | 0.297c |
| Average Rx Medications (SD) | 5.03 (3.26) | 4.34 (2.52) | 4.61 (2.83) | 0.257a |
| High mCES-D, n(%) | 1 (2.6) | 4 (6.3) | 5 (4.9) | 0.647c |
| Family History of Memory Problems, n(%) | 9 (23.1) | 20 (31.7) | 29 (28.4) | 0.346b |
| Current Smoker, n(%) | 1 (2.6) | 7 (11.1) | 8 (7.4) | 0.150c |
| Current Drinker, n(%) | 28 (71.8) | 45 (71.4) | 73 (71.6) | 0.968b |
Note: Aβ=amyloid-beta, SD=standard deviation, HS=High School, MMSE=Mini-mental State Examination, CDR=Clinical Dementia Rating, TIA=Transient Ischemic Attack, mCES-D=modified Center for Epidemiologic Studies Depression Scale
^
Three participants missing APOE data
p-values reflect tests for significant differences between Aβ(+) and Aβ(−) groups using:
a
T-test
b
Pearsons Chi-Square
c
Fisher’s Exact Test