Table 3.
Adjusted Regression Analyses^ Predicting Cross Sectional Cognitive Performance with Aβ and Tau
| Primary Predictor | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Global Aβ | Braak 1 Tau | Braak 3/4 Tau | Braak 5/6 Tau | |||||||||
| Cognitive Outcome | B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | B | 95% CI | p |
| Global Cognition | −0.017 | (−0.411, 0.377) | 0.931 | 0.188 | (−0.596, 0.972) | 0.635 | 1.405 | (−0.345, 3.155) | 0.114 | 1.560 | (−0.145, 3.264) | 0.072 |
| Attention domain | 0.004 | (−0.542, 0.550) | 0.988 | 0.304 | (−0.781, 1.389) | 0.579 | 2.073 | (−0.293, 4.440) | 0.085 | 2.062 | (−0.264, 4.388) | 0.082 |
| Executive Function domain | 0.045 | (−0.421, 0.511) | 0.848 | 0.313 | (−0.612, 1.238) | 0.503 | 1.261 | (−0.774, 3.297) | 0.222 | 1.383 | (−0.615, 3.381) | 0.173 |
| Language domain | −0.298 | (0.723, 0.127) | 0.168 | −0.073 | (−0.927, 0.781) | 0.866 | 1.325 | (−0.545, 3.196) | 0.163 | 1.599 | (−0.230, 3.429) | 0.086 |
| Memory domain | 0.071 | (−0.439, 0.581) | 0.784 | −0.012 | (−1.027, 1.004) | 0.982 | 1.268 | (−1.011, 3.548) | 0.272 | 1.513 | (−0.708, 3.734) | 0.18 |
| Visual Spatial Reasoning domain | 0.207 | (−0.449, 0.862) | 0.531 | 1.851 | (0.396, 3.306) | 0.013 | 1.710 | (−1.543, 4.963) | 0.298 | 0.999 | (−2.159, 4.157) | 0.53 |
| Face Name Association Test | 0.138 | (−2.787, 3.063) | 0.925 | 1.094 | (−4.734, 6.921) | 0.710 | 8.238 | (−4.523, 21.000) | 0.203 | 6.164 | (−6.502, 18.831) | 0.336 |
| LASSI-L Test Components | ||||||||||||
| Cued A1 Total | −0.125 | (−1.582, 1.332) | 0.865 | −0.754 | (−3.659, 2.152) | 0.608 | 0.654 | (−5.887, 7.194) | 0.843 | 0.683 | (−5.706, 7.073) | 0.832 |
| Cued A2 Total | −0.113 | (−1.204, 0.978) | 0.838 | 0.272 | (−1.907, 2.450) | 0.805 | 1.202 | (−3.692, 6.095) | 0.627 | 0.219 | (−4.567, 5.006) | 0.928 |
| Cued B1 Total | −0.238 | (−1.599, 1.124) | 0.73 | −0.979 | (−3.693, 1.736) | 0.476 | −1.423 | (−7.535, 4.689) | 0.645 | −0.047 | (−6.026, 5.931) | 0.988 |
| Cued B2 Total | −0.655 | (−1.790, 0.480) | 0.255 | −0.877 | (−3.153, 1.400) | 0.446 | −1.939 | (−7.058, 3.180) | 0.454 | −2.229 | (−7.224, 2.766) | 0.378 |
| Cued A3 Total | −1.125 | (−2.487, 0.237) | 0.104 | −2.967 | (−5.657, −0.278) | 0.031 | −2.704 | (−8.885, 3.477) | 0.387 | −1.589 | (−7.644, 4.466) | 0.603 |
| DR Correct | −2.481 | (−4.924, −0.038) | 0.047 | −2.728 | (−7.724, 2.268) | 0.281 | −4.898 | (−16.108, 6.313) | 0.388 | −2.250 | (−13.327, 8.827) | 0.687 |
| DR Intrusions | 0.891 | (0.210, 1.524) | 0.007 | −0.168 | (−1.826, 1.369) | 0.837 | −2.228 | (−5.614, 1.247) | 0.203 | −0.414 | (−3.836, 3.043) | 0.814 |
Note: Aβ=amyloid-beta, CI=Confidence Interval, LASSI-L= Loewenstein-Acevedo Scale for Semantic Interference and Learning – II Edition, DR=Delayed Recall.
Cells contain raw beta-coefficients
Bonferroni-corrected α=.004
^
Linear regression (Attention, Executive Function, Language, Memory, Visual Spatial Reasoning, Face Name, DR Correct), Poisson Regression (DR Intrusions), All model adjusted for age, sex, education, and cohort.