Table II.
Maternal and neonatal characteristics of infants by study group
| PHVD group N=815 |
Intracranial Hemorrhage without PHVD N=769 |
Normal HUS N=2632 |
P-valuea | |
|---|---|---|---|---|
| Maternal variables | ||||
| Age of mother (mean(SD))- years | N=813 27.55(6.38) |
N=768 28.07(6.42) |
28.21(6.13) | 0.02 |
| Antenatal steroids –n (%) | 650/813(80.0) | 660/767(86.0) | 2419/2629(92.0) | <0.01 |
| Complete-n (%) | 423/648(65.3) | 482/656(73.5) | 1922/2411(79.7) | <0.01 |
| Partial-n (%) | 225/648(34.7) | 174/656(26.5) | 489/2411(20.3) | <0.01 |
| Delivery mode: Vaginal- n (%) | 343/815(42.1) | 344/769(44.7) | 854/2632(32.4) | <0.01 |
| Histological chorioamnionitis- n (%) | 446/710(62.8) | 398/685(58.1) | 1296/2325(55.7) | <0.01 |
| Hypertension/preeclampsia-n (%) | 136/812(16.7) | 162/766(21.1) | 649/2626(24.7) | <0.01 |
| Maternal education < high school- n(%) | 137/616(22.2) | 127/609(20.9) | 389/2066(18.8) | 0.14 |
| Race: Black- n(%) |
357/779(45.8) | 334/751(44.5) | 1140/2563(44.5) | 0.79 |
| White- n(%) | 395/779(50.7) | 370/751(49.3) | 1266/2563(49.4) | 0.80 |
| Other- n(%) | 27/779(3.5) | 47/751(6.3) | 157/2563(6.1) | 0.01 |
| Neonatal Variables | ||||
| Outborn-n (%) | 38/815(4.66) | 29/769(3.77) | 83/2632(3.15) | 0.12 |
| Gestational age –wks (mean(SD)) | 24.32(1.16) | 24.65(1.12) | 24.95(1.03) | <0.01 |
| Birth weight g (mean(SD) ) | 706.31( 161.88) | 729.19(164.04) | 746.62( 168.62) | <0.01 |
| Male -n (%) | 456/815(56.0) | 430/767(56.1) | 1284/2630(48.8) | <0.01 |
| Delivery room intubation-n (%) | 734/815(90.1) | 630/768(82.0) | 2043/2632(77.6) | <0.01 |
| Surfactant use-n (%) | 792/815(97.2) | 716/769(93.1) | 2370/2632(90.0) | <0.01 |
| Postnatal steroids- n (%) | 178/745(23.9) | 160/718(22.3) | 558/2429(23.0) | 0.76 |
| Oxygen at 36 weeks- n (%) | 425/565(75.2) | 383/619(61.9) | 1414/2319(61.0) | <0.01 |
| Necrotizing enterocolitis > Stage 2- n (%) | 106/815(13.0) | 78/769(10.1) | 275/2632(10.4) | 0.09 |
| Late onset sepsis - n (%) | 253/761(33.2) | 240/740(32.4) | 642/2587(24.8) | <0.01 |
| Retinopathy of prematurity requiring therapy- n (%) | 134/580(23.1) | 104/621(16.7) | 261/2309(11.3) | <0.01 |
| Hemorrhage Grade Grade I |
22/815(2.7) | 343/769(44.6) | - | - |
| Grade II | 37/815(4.5) | 324/769(42.1) | - | - |
| Grade III | 354/815(43.4) | 0/769(0.0) | - | - |
| Grade IV | 402/815(49.3) | 102/769(13.3) | - | - |
| Days to first intervention for PHVD- median(IQR) overall | n=119 33(25,56) |
|||
| VPS | n=53 39(31,78) |
|||
| Ventricular reservoir | N=66 29(23,44) |
|||
| PMA at first intervention for PHVD (weeks)- median(IQR) overall | n=119 29.7(28.6,32.0) |
|||
| VPS | n=53 30.7(29.0,36.6) |
|||
| Ventricular reservoir | N=66 29.1(27.9,31.3) |
a
P-values obtained using chi-square test or Fisher’s exact test for categorical and Nonparametric Wilcoxon test for continuous outcomes.