Table V.
18-26 months corrected age outcome among infants with no intervention vs. intervention among infants with PHVD only.
| No intervention | With intervention (VPS or VR) |
Adjusted odds ratio (95% CI) a or Estimates (95% CI)a PHVD with intervention vs. PHVD with no Intervention. |
|
|---|---|---|---|
| Death or Neurodevelopmental impairment- n (%) | 420/641(65.5) | 86/107(80.4) | 1.97(1.15,3.38)* |
| Neurodevelopmental impairment | 142/363(39.1) | 69/90(76.7) | 4.28(2.44,7.51)*** |
| Death -n (%) (beforec/after DC) | 278/695(40.0) | 17/119(14.3) | 0.18(0.10,0.32)*** |
| Normal outcome in survivorsd- n (%) | 114/369(30.9) | 9/91(9.9) | 0.32(0.15,0.69)** |
| Cerebral Palsy- n (%) | 133/380(35.0) | 69/91(75.8) | 4.56(2.63,7.93)*** |
| BSID III Cognitive > 85- n (%) | 139/369(37.7) | 11/83(13.3) | 0.28(0.14,0.57)*** |
| 70-85 -n (%) | 142/369(38.5) | 26/83(31.3) | 0.79(0.47,1.36) |
| 69-55- n (%) | 73/369(19.8) | 38/83(45.8) | 2.85(1.66,4.88)*** |
| < 55 - n (%) | 15/369(4.07) | 8/83(9.64) | 2.50(0.95,6.62) |
| Motor composite score > 85 n (%) | 138/353(39.1) | 11/81(13.6) | 0.30(0.15,0.60)*** |
| 70-85 -n (%) | 111/353(31.4) | 14/81(17.3) | 0.48(0.26,0.92)* |
| 69-55 -n (%) | 52/353(14.7) | 25/81(30.9) | 2.23(1.24,4.00)** |
| <55 -n (%) | 52/353(14.7) | 31/81(38.3) | 3.17(1.75,5.73)*** |
| Hearing impairment -n (%) | 18/378(4.76) | 7/91(7.69) | 1.85(0.71,4.85) |
| Vision impairment - n (%) | 15/379(3.96) | 12/90(13.3) | 3.53(1.51,8.27)** |
| Rehospitalized-n (%) | 208/383(54.3) | 69/91(75.8) | 2.41(1.40,4.14)** |
| Rehospitalization for seizures or VPS revision- n (%) | 20/207(9.7) | 26/69(37.7) | 5.07(2.48,10.37)*** |
| Growth: | |||
| Weight kgs (mean(SD) | N=381 11.66(4.64) |
N=90 11.09(1.63) |
−0.34(−1.37,0.68) |
| Height cms, (mean(SD) ) | N=373 84.13(5.06) |
N=90 83.15(5.07) |
−0.88(−2.08,0.31) |
| Head circumference cms (mean(SD) ) | N=378 47.05(2.42) |
N=91 45.93(2.98) |
−1.07(−1.67,−0.48)*** |
| Weight<10th percentile - n (%) | 82/381(21.5) | 28/90(31.1) | 1.38(0.81,2.36) |
| Height< 10th percentile - n (%) | 139/373(37.3) | 42/90(46.7) | 1.37(0.84,2.23) |
| Head circumference < 10th percentile - n (%) | 102/378(27.0) | 47/91(51.6) | 2.50(1.52,4.11)*** |
Adjusted odds ratio (95% CI) for categorical outcomes has been obtained using Generalized Linear Mixed models. For continuous outcome, adjusted estimates (95% CI) were obtained using Generalized Linear Models. Covariates adjusted in all models are center, mothers’ education, and gestational age and parenchymal hemorrhage. Center variations have been adjusted as a random effect for categorical outcomes.
Neurodevelopmental impairment was defined as moderate/severe cerebral palsy or Bayley III cognitive or motor score <70, blindness or deafness.
Withdrawal of respiratory support among those who died prior to hospital discharge was 26.7% among infants with no intervention and 5.9% among those with intervention, P <.001
Normal outcome in survivors is defined as no cerebral palsy, Bayley III cognitive composite score ≥85, motor composite score ≥85, no blindness and no deafness.
P<.05
P <.01
P <.001