Skip to main content
. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Nov 30;60(5):2472–2477. doi: 10.1002/anie.202012048

Figure 5.

Figure 5.

Scope of the reductive arylation of aliphatic amides and aryl boronates. Standard conditions unless otherwise noted: amide substrate (0.20 mmol, 1.0 equiv); aryl boronate (0.80–1.2 mmol, 4.0–6.0 equiv); 7 (0.50 mmol, 2.5 equiv); K3PO4 (0.80 mmol, 4.0 equiv); H2O (0.40 mmol, 2.0 equiv); Ni(cod)2 (0.020–0.040 mmol, 10–20 mol%); 2 (0.040–0.080 mmol, 20–40 mol%); solvent (1.0 M); 120 °C; 16–24 h. Unless otherwise noted, yields reflect the average of two isolation experiments. [a] Yield determined by 1H NMR analysis using 1,3,5-trimethoxybenzene as an external standard.