Table 4.

Biomarker Expression in Baseline and 3-Month Post-Treatment Endometrial Biopsy Specimens

Biomarker	Protein Expression
	Responders (CR+PR)	Non Responders (PD+SD)	P Value*
Ki67, # positive nuclei in 10 HPF, median (range)(N=17)
Baseline	27.5 (4.0 – 73.0)	65.5 (32.0 – 91.0)	0.023
3 month change	−16.0 (−68.0 – 4.0)	−18.5 (−87.0 – 8.0)	0.828
PgR, % positive nuclei, median (range) (n = 11)
Baseline	70.0 (50.0 – 90.0)	80.0 (70.0 – 90.0)	0.437
3 month change	−40.0 (−85.0 – 0)	−20.0 (−50 - −10)	0.704
	Normalized Gene Expression (%18S rRNA)
	Responders (CR+PR) (n = 10)	NonResponders (PD+SD) (n = 4)	P Value*
PgR, median (range)
Baseline	0.783 (0.046 – 2.136)	0.541 (0.293 – 1.040)	0.407
3 month change	−0.622 (−2.036 – 0.092)	−0.248 (−0.816 – 0.326)	0.203
EIG121, median (range)
Baseline	0.039 (0.001 – 0.132)	0.011 (0.004 – 0.074)	0.238
3 month change	−0.036 (−0.110 – 0.005)	0.003 (−0.049 – 0.057)	0.090
IGF-1, median (range)
Baseline	0.039 (0.002 – 0.293)	0.003 (0.000 – 0.118)	0.176
3 month change	−0.043 (−0.284 – 0.019)	−0.018 (−0.0115 – 0.001)	0.888
IGF-2, median (range)
Baseline	0.065 (0.002 – 5.673)	0.046 (0.002 – 0.281)	0.827
3 month change	0.239 (−5.263 – 1.469)	−0.003 (−0.235 – 0.777)	0.203
IGFBP1, median (range)
Baseline	0.004 (0.000 – 0.558)	0.005 (0.001 – 0.019)	>0.999
3 month change	36.351 (11.961 – 85.746)	0.960 (0.003 – 55.487)	0.066
RALDH2, median (range)
Baseline	0.102 (0.005 – 0.408)	0.016 (0.006 – 0.184)	0.176
3 month change	0.073 (−0.077 – 0.170)	−0.017 (−0.080 – 0.007)	0.034
SFRP1, media (range)
Baseline	0.747 (0.036 – 12.020)	0.210 (0.029 – 0.655)	0.089
3 month change	−0.628 (−3.625 – 0.368)	0.372 (−0.128 – 1.080)	0.024
SFRP4, median (range)
Baseline	0.871 (0.012 – 6.508)	0.256 (0.009 – 2.579)	0.150
3 month change	−0.891 (−6.504 – 0.050)	−0.429 (−2.567 – 0.029)	0.396
Survivin, median (range)
Baseline	0.003 (0.000 – 0.010)	0.007 (0.001 – 0.011)	0.174
3 month change	−0.002 (−0.009 – 0.007)	−0.003 (−0.009 – 0.007)	0.436
DKK3, median (range)
Baseline	0.081 (0.047 – 0.304)	0.036 (0.021 – 0.051)	0.030
3 month change	−0.042 (−0.212 – 0.103)	0.002 (−0.016 – 0.019)	0.667
FZD8, median (range)
Baseline	0.162 (0.118 – 0.390)	0.245 (0.063 – 0.274)	>0.999
3 month change	−0.078 (−0.202 – 0.026)	0.073 (0.033 – 0.112)	0.032
FZD10, median (range)
Baseline	0.792 (0.365 – 3.670)	1.639 (0.593 – 1.715)	0.470
3 month change	−0.511 (−2.688 – 0.091)	0.727 (−0.236 – 1.690)	0.086
TCF7, median (range)
Baseline	0.124 (0.056 – 0.258)	0.094 (0.080 – 0.116)	0.248
3 month change	−0.064 (−0.160 – 0.179)	0.109 (0.022 – 0.196)	0.053
Wnt5a, median (range)
Baseline	1.882 (0.497 – 3.840)	0.881 (0.611 – 1.919)	0.194
3 month change	2.282 (0.696 – 7.317)	1.238 (0.493 – 1.984)	0.197

HPF, high-power fields.