Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Immunol. 2020 Nov 23;206(1):132–140. doi: 10.4049/jimmunol.2000870

Figure 6.

Figure 6.

Loss of IL-18 signaling results in hyporesponsive splenic iNKT cells, however hepatic iNKT cells respond normally. (A) Frequency and (B) absolute number of iNKT cells (CD45+TCRβ+CD1dtet+) from the spleen and liver of C57BL/6 (black) or IL-18−/− (open) mice at 36 hours post-infection with MCMV. (C) Frequency and (D) representative flow cytometry of IFN-γ+ iNKT cells (CD45+TCRβ+CD1dtet+) and (E) frequency of CD69+ iNKT cells (CD45+TCRβ+CD1dtet+) from the spleen and liver of indicated mice at 36 hours post-MCMV. (F) Frequency of IFN-γ+ NK cells (CD45+TCRβ−NK1.1+) from the spleen and liver of indicated mice at 36 hours post-MCMV. Data are pooled from or representative of two independent experiments (n=8) and error bars indicate SEM.