Table 2.
Infant Outcomes by Maternal HBV VL Status
| HBV VL <106 IU/ml vs HIV | HBV VL ≥106 IU/ml vs HIV | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome N=2041 | HIV N=1953 | HBV VL <106 IU/ml N=78 | p | Adj P | HBV VL ≥106 IU/ml N=10 | p | Adj P | Odds Ratio (OR) | |
| Low Birth Weight (grams) | >2500 | 1759(90) | 73(94) | 0.43 | 0.38 | 7(70) | 0.07 | 0.04 | 3.99(1.04-15.3) |
| ≤2500 | 194(10) | 5(6) | 3(30) | ||||||
| Median Birth Weight (kilograms) | 3.1 (2.8-3.4) | 3.2 (3-3.5) | 0.03 | 3.1 (2.4-3.5) | 0.94 | ||||
| 3.1 +/− 0.43 | 3.2 +/− 0.42 | 3.06 +/− 0.51 | |||||||
| Congenital Malformation | Yes | 83(4) | 2(3) | 0.77 | 0.68 | 0 | 1.00 | 0.96 | 1.07(0.05-21.0) |
| HIV Infection at Any Time | Yes | 71(4) | 0 | 0.11 | 0.23 | 2(20) | 0.05 | 0.01 | 6.89(1.48-32.1) |
| Death at Any Time | Yes | 75(4) | 0 | 0.11 | 0.18 | 0 | 1.00 | 1.00 | 1.00(0.05-19.5) |
| HIV Infection at Any Time/Low Birth Weight | Yes | 254(13) | 5(6) | 0.12 | 0.13 | 4(40) | 0.03 | 0.02 | 4.33(1.21-15.5) |
Table 2 represents the results of multivariable analysis (adjusted p value) and odds ratio where covariates for infant low birth weight and congenital malformations were maternal age, maternal CD4 at delivery, and maternal receipt of ART during pregnancy (yes/no). Odds ratio represents the comparison between women with HBV VL ≥106 IU/ml vs women with HIV alone. Covariates for infant HIV infection and death and the composite endpoint of HIV infection at any time and low birth weight were maternal age, maternal CD4 count at delivery, maternal receipt of ART during pregnancy (yes/no), and infant nevirapine treatment assignment (no NVP, 6 weeks of NVP, and 6 months of NVP).