Table 1.
Descriptive characteristics of BRCA noncarrier male breast cancer cases and controls
| BRCA (−) male breast cancer cases | Controls | ||
|---|---|---|---|
| (n=3647) | (n=4269) | ||
| No. (%) | No. (%) | P* | |
| Age at index cancer diagnosis, years | |||
| Median (interquartile range) | 62 (53 – 69) | 46 (40 – 53) | <0.001 |
| 20–29 | 26 (0.7) | 180 (4.2) | <0.001 |
| 30–39 | 135 (3.7) | 863 (20.2) | |
| 40–49 | 491 (13.5) | 1746 (40.9) | |
| 50–59 | 931 (25.5) | 829 (19.4) | |
| 60–69 | 1230 (33.7) | 438 (10.3) | |
| 70–79 | 834 (22.9) | 213 (5.0) | |
| Ethnicity | |||
| White/European | 2533 (69.5) | 2848 (66.7) | <0.001 |
| Black | 286 (7.8) | 255 (6.0) | |
| Asian | 54 (1.5) | 141 (3.3) | |
| Latino | 131 (3.6) | 288 (6.7) | |
| Native American | 43 (1.2) | 66 (1.5) | |
| Near/Middle Eastern | 34 (0.9) | 38 (0.9) | |
| Other | 34 (0.9) | 48 (1.1) | |
| Multi-ethnic | 532 (14.6) | 585 (13.7) | |
| Ashkenazi ancestry | |||
| No | 3336 (91.5) | 4142 (97.0) | <0.001 |
| Yes | 311 (8.5) | 127 (3.0) | |
| Year of testing | |||
| 2006 | 105 (2.9) | 148 (3.5) | 0.012 |
| 2007 | 433 (11.9) | 427 (10.0) | |
| 2008 | 468 (12.8) | 588 (13.8) | |
| 2009 | 517 (14.2) | 686 (16.1) | |
| 2010 | 670 (18.4) | 799 (18.7) | |
| 2011 | 701 (19.2) | 791 (18.5) | |
| 2012 | 753 (20.6) | 830 (19.4) | |
| Any VUS | |||
| No | 3584 (98.3) | 4005 (93.8) | <0.001 |
| Yes | 63 (1.7) | 264 (6.2) | |
| Personal history of non-breast/colon cancer | |||
| No | 3240 (88.8) | 3236 (75.8) | <0.001 |
| Yes | 407 (11.2) | 1033 (24.2) |
*
Wilcoxon rank-sum test for comparison of medians and χ2 test for categorical variables