Table 3.

Family history of breast cancer among male breast cancer cases who are noncarriers of BRCA mutations, stratified by affected relatives’ gender

	BRCA (−) male breast cancer cases (n=3647)	Controls (n=4269)	Adjusted ORa	(95% CI)
No affected first- or second-degree relative	2007 / 3647	3636 / 4269	1.0	Reference
Any affected first- or second-degree relative
Male relative affected	66	7	17.9	(7.6, 42.1)
Female relative affected	1601	629	4.6	(4.0, 5.2)
Both male and female relatives affected	28	3	15.7	(4.4, 55.3)
Any affected first-degree relative
Male relative affected	31	4	10.8	(3.4, 34.1)
Female relative affected	1017	371	4.2	(3.6, 4.9)
Both male and female relatives affected	12	1	15.1	(1.8, 126.1)
Any affected second-degree relative
Male relative affected	36	3	27.6	(7.7, 98.3)
Female relative affected	862	317	6.1	(5.2, 7.2)
Both male and female relatives affected	9	1	25.7	(3.0, 220.0)
No first-degree affected relative, second-degree relative affected only
Male relative affected	24	3	20.1	(5.3, 75.8)
Female relative affected	582	257	5.4	(4.5, 6.5)
Both male and female relatives affected	3	1	8.3	(0.8, 91.6)
Number of affected first-degree relatives
1 affected male first-degree relative	29	4	9.2	(2.9, 29.4)
2+ affected male first-degree relatives	2	0	-	-
1 affected female first-degree relative	824	337	3.9	(3.3, 4.6)
2+ affected female first-degree relatives	193	34	7.5	(5.0, 11.4)
Both male and female first-degree relatives affected	12	1	15.1	(1.8, 126.1)

^aMultivariable unconditional logistic regression models adjusted for: age, year of testing, and ethnicity.