Fig 1.

Experimental timeline. Subjects received a structural MRI scan and were trained on a touch screen to perform a Delayed Match to Sample (DMS) task and a stimulus discrimination with reversal learning (RevL) task prior to assignment into one of two groups (cocaine self-administration (N=8), water self-administration (SA) control (N=6)). Cocaine animals self-administered intravenously up to 3.0mg/kg cocaine 4 days a week, while control subjects performed similar tasks for water reward. Cognitive performance on DMS and RevL tasks were assessed on alternating Mondays.