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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2020 Aug 1;12(2):e1620. doi: 10.1002/wrna.1620

Figure 5. Brat regulates neurogenesis.

Figure 5.

A. Brat controls early differentiation of Drosophila Type II neuroblasts in the larval brain. During asymmetric cell division, Miranda (Mira) localizes and concentrates Brat in the nascent Intermediate Neural Progenitor (INP). Following cytokinesis, Mira is degraded, releasing Brat. During INP maturation, Brat is reduced and transcription factors Asense and Deadpan are expressed. These transcription factors promote further asymmetric divisions of INPs, forming glial cells and neurons.

B. Proposed RNA-dependent and -independent regulatory roles of Brat in INP maturation. Activation is indicated by pointed arrows whereas repression is marked with blunted arrows. Observed physical associations of Brat with the RNA-binding protein Tis11 and CNOT deadenylase complex are marked with bulb-end lines. Translational control (TL) and transcriptional control (TX) are indicated on the respective arrows.