Table 3A.
Multivariable logistic regression (with generalized logic link) analyses of factors associated with annual change in estimated glomerular filtration rate as calculated by the CKiD Cr-CysC equation with ‘Stable’ as the reference group (n=1206) among SEARCH participants with type 1 diabetes.
| Type 1 DM | Overall p-value | Decline (vs Stable) | Rise (vs Stable) | ||||
|---|---|---|---|---|---|---|---|
| OR | 95%CI | p-value | OR | 95%CI | p-value | ||
| Female sex | <0.0001 | 0.3 | 0.2, 0.4 | <0.0001 | 5.5 | 2.0, 14.7 | 0.0007 |
| NH Black race | 0.7 | 1.0 | 0.6, 1.8 | 1.0 | 0.6 | 0.2, 2.1 | 0.4 |
| Age at diagnosis (years) | 0.0001 | 1.1 | 1.0, 1.1 | 0.003 | 1.2 | 1.1, 1.4 | 0.001 |
| Time from baseline visit (years) | <0.0001 | 0.8 | 0.7, 0.8 | <0.0001 | 0.5 | 0.3, 0.6 | <0.0001 |
| Baseline eGFR (ml/min/1.73m2) (10 unit increase) | <0.0001 | 1.7 | 1.6, 1.9 | <0.0001 | 0.9 | 0.8, 1.2 | 0.6 |
| Glucose change from baseline (mg/dl) (50 unit increase) | <0.0001 | 0.8 | 0.8, 0.9 | <0.0001 | 1.3 | 1.1, 1.5 | 0.002 |
| HbA1c (%) (AUC) | <0.0001 | 0.7 | 0.6, 0.8 | <0.0001 | 2.0 | 1.5, 2.7 | <0.0001 |
| Body mass index Z-score (AUC) | <0.0001 | 1.5 | 1.2, 1.8 | <0.0001 | 1.0 | 0.6, 1.6 | 1.0 |
| Systolic Blood pressure Z-score (AUC) | 0.002 | 0.7 | 0.6, 0.8 | 0.0004 | 0.9 | 0.6, 1.5 | 0.7 |
*
Multivariable model also adjusts for geographic site