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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Genomics. 2020 Dec 2;113(1 Pt 1):111–119. doi: 10.1016/j.ygeno.2020.11.032

Table 2. Background selection enrichments.

Seven phenotypes whose observed scale SNP-based heritability (SNP-h2) estimates demonstrated significant enrichment (q<0.05) of background selection (BGS) in at least one genomic annotation of per-SNP B-statistic measures. FDR significant observations (q<0.05) are in bold text.

Trait BGS (top 2%) SNP-h2 Fold Enrichment (p) BGS (top 1%) SNP-h2 Fold Enrichment (p) BGS (top 0.5%) SNP-h2 Fold Enrichment (p)
Bipolar Disorder 2.62 (2.01×10−6) 3.01 (4.31×10−6) 2.36 (0.021)
Cognitive Performance 2.29 (1.81×10−8) 2.90 (7.31×10−6) 3.24 (0.001)
Drinks Per Week 2.25 (8.33×10−7) 2.43 (0.004) 3.29 (0.006)
Educational Attainment 1.86 (9.69×10−6) 2.04 (0.001) 2.53 (0.003)
Schizophrenia 1.90 (7.29×10−6) 2.23 (6.04×10−6) 2.27 (0.007)
Reaction Time 2.02 (1.33×10−7) 2.13 (0.001) 2.44 (0.018)
Verbal Numeric Reasoning 2.35 (8.63×10−8) 2.63 (2.21×10−4) 2.81 (0.017)