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. Author manuscript; available in PMC: 2022 Feb 5.
Published in final edited form as: Eur J Med Chem. 2020 Dec 3;211:113060. doi: 10.1016/j.ejmech.2020.113060

Scheme 6.

Scheme 6.

Synthesis of N-2 substituted analogsa

aReagents and Conditions: (a) R1-Br, R2-Br or R2-OMs, K2CO3, DMF, 20-80 °C; (b) 1-bromoethylbenzene, diethyl 2-bromo-2-methylmalonate, K2CO3, DMF, 20-50 °C; (c) NaBH4, Br2, dimethoxyethane, −20 °C to RT; (d) nBuLi, Ts-Cl, THF, −78 °C to RT; (e) nBuLi, THF, 0-80 °C.