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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Pain. 2020 Jul 30;22(2):180–195. doi: 10.1016/j.jpain.2020.03.009

Figure 4.

Figure 4

Effect of peri-sciatic nerve injection of 0.25% nanoparticle (Nano)-coated ropivacaine (RVC), 0.25% free ropivacaine, or vehicle on paw withdrawal responses to mechanical (a and c) and heat (b and d) stimuli on the ipsilateral (a and b) and contralateral (c and d) sides at different time points as indicated after incision. Data are expressed as the mean ± S.E.M of 6 rats per group. Two-way ANOVA with repeated measures followed by post hoc Tukey test. *P < 0.05 comparison between the 0.25% nanoparticle-coated ropivacaine-treated incisional group and the vehicle-treated incisional group at the corresponding time point. #P < 0.05 or ##P < 0.01 comparison between the 0.25% free ropivacaine-treated incisional group and the vehicle-treated incisional group at the corresponding time point.