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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: J Mech Behav Biomed Mater. 2020 Nov 22;114:104220. doi: 10.1016/j.jmbbm.2020.104220

Figure 3.

Figure 3.

Elastic modulus for ribose modified kidney ECM versus ribose concentration with and without AGE inhibitors DTPA (10 mM) and PM (20 mM). Ribose incubation increased ECM stiffness in a dose-dependent manner. Post-hoc Dunnett’s testing for multiple comparisons was used to evaluate differences from the control. * denotes statistically significant differences in elastic modulus induced by ribose relative to control. † denotes statistically significant reductions in stiffness as compared to ribose at a given concentration, n=4 for all conditions. The solid line is the least squares fit of the data to an exponential function of the form y=c1+c2(1-e−c3x). DTPA and PM reduced ribose induced increases in ECM stiffness. PM reduced ECM stiffness at all concentrations. DTPA reduced ECM stiffness in a statistically significant manner at 100 mM ribose. Data are shown at the mean±SEM. Data were analyzed by two-way ANOVA. Solid lines are best-fit curves based on an exponential function.