Figure 9.

Hyperdopaminergic mice show increased vulnerability to ABA. All mice were tested in the ABA condition. (A) Bodyweight across days of food restriction. (B) Bodyweight of individual mice (light traces) across days of food restriction (bold lines indicate group average). (C) Survival curves for each group. Numbers indicate number of surviving mice that day. (D) Daily food intake across days of restriction. (E) Average food intake prior to removal versus the day of removal. (F) Correlation between consumption during restricted access to food and changes in body weight the next day. Each symbol represents one animal on one experimental day. (G) Average wheel activity across days of food restriction. (H) Wheel running of individual mice (light traces) and group mean (bold traces) across food restriction for (H1) light and (H2) dark cycle running. (I) Maximum increase in wheel running across two consecutive days (averaged by group) during the light and dark cycle. (J) Histogram of the percentage of mice that exhibited peak increase in light cycle running on each day of food restriction. (K) Correlation between light (left) or dark cycle running (right) and change in bodyweight the next day. Each symbol represents one animal on one experimental day. Food intake data: n=12 (DAT^+/+), n=8 (DAT^cre/+); All other data: n=16 (DAT^+/+), n=11 (DAT^cre/+). ^†Survival curves, p<0.05; ***p<0.001. Error bars, ±SEM.