Table 3:
Univariable associations of 1st degree family history of cardiovascular disease with cardiovascular outcomes among survivors exposed and unexposed to cardiotoxic therapy
| Cardiovascular Outcomes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular Disease | Cardiovascular Risk Factors | ||||||||||
| Atherosclerotic Disease (AD) | |||||||||||
| MI (N=73) | Stroke (N=24) | Heart Failure (N=145) | HTN (N=249) | Diabetes (N=75) | |||||||
| First Degree Family History among Survivors Exposed to Cardio- toxic Therapy (n=824) |
N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | |
| 1st⁰ FH of identical outcome | 12 | 0.9 (0.5-1.5) | 4 | 1.6 (0.6-4.6) | 9 | 0.9 (0.5-1.7) | 194 | 2.1 (1.6-2.8) | 35 | 2.0 (1.3-3.0) | |
| No FH | 61 | 1.0 | 20 | 1.0 | 136 | 1.0 | 55 | 1.0 | 40 | 1.0 | |
| 1st⁰ FH of CVD | 25 | 1.3 (0.8-2.1) | 8 | 1.3 (0.6-2.9) | 54 | 1.5 (1.1-2.0) | 105 | 1.9 (1.5-2.3) | 34 | 2.1 (1.4-3.2) | |
| No FH | 48 | 1.0 | 16 | 1.0 | 91 | 1.0 | 144 | 1 | 41 | 1.0 | |
| Early* 1st⁰ FH of AD | 16 | 1.4 (0.8-2.3) | 6 | 1.6 (0.7-4.0) | 32 | 1.4 (1.0-1.9) | 66 | 1.7 (1.4-2.2) | 21 | 1.9 (1.2-3.0) | |
| No FH | 57 | 1.0 | 18 | 1.0 | 113 | 1.0 | 183 | 1 | 54 | 1.0 | |
| 1st⁰ FH of AD | 24 | 1.4 (0.9-2.2) | 6 | 1.0 (0.4-2.4) | 50 | 1.5 (1.1-2.0) | 96 | 1.8 (1.5-2.2) | 30 | 1.9 (1.2-3.0) | |
| No FH | 49 | 1.0 | 18 | 1.0 | 95 | 1.0 | 153 | 1 | 45 | 1 | |
| 1st⁰ FH of CVRF | 55 | 1.4 (0.8-2.3) | 13 | 0.5 (0.2-1.2) | 111 | 1.5 (1.1-2.1) | 205 | 2.1 (1.6-2.9) | 59 | 1.7 (1.0-2.9) | |
| No FH | 18 | 1 | 11 | 1.0 | 34 | 1.0 | 44 | 1 | 16 | 1.0 | |
| 1st⁰ FH of CVD or CVRF | 59 | 1.5 (0.9-2.7) | 14 | 0.5 (0.2-1.1) | 118 | 1.6 (1.1-2.3) | 217 | 2.5 (1.8-3.4) | 64 | 2.1 (1.1-3.9) | |
| No FH | 14 | 1.0 | 10 | 1.0 | 27 | 1.0 | 32 | 1 | 11 | 1.0 | |
| First Degree Family History Among Survivors Unexposed to Cardio toxic Therapy (n=436) |
MI (N=14) | Stroke (N=15) | Heart Failure (N=15) | HTN (N=140) | Diabetes (N=43) | ||||||
| N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | N | RR (95% CI) | ||
| 1st⁰ FH of identical outcome | 6 | 2.6 (0.9-7.4) | 1 | 0.5 (0.1-3.9) | 6 | 9.4 (3.6-24.5) | 105 | 1.6 (1.1-2.2) | 24 | 2.6 (1.5-4.5) | |
| No FH | 8 | 1.0 | 14 | 1.0 | 9 | 1.0 | 35 | 1.0 | 19 | 1.0 | |
| 1st⁰ FH of CVD | 7 | 2.2 (0.8-6.1) | 4 | 0.8 (0.3-2.4) | 9 | 3.3 (1.2-9.0) | 58 | 1.5 (1.2-2.0) | 17 | 1.4 (0.8-2.5) | |
| No FH | 7 | 1.0 | 11 | 1.0 | 6 | 1.0 | 82 | 1.0 | 26 | 1.0 | |
| Early* 1st⁰ FH of AD | 5 | 2.5 (0.9-7.2) | 2 | 0.7 (0.2-3.0) | 5 | 2.2 (0.8-6.3) | 35 | 1.5 (1.1-2.0) | 13 | 1.9 (1.1-3.5) | |
| No FH | 9 | 1.0 | 13 | 1.0 | 10 | 1.0 | 105 | 1.0 | 30 | 1.0 | |
| 1st⁰ FH of AD | 6 | 1.9 (0.7-5.4) | 4 | 0.9 (0.3-2.9) | 7 | 2.2 (0.8-6.0) | 53 | 1.6 (1.2-2.0) | 16 | 1.5 (0.8-2.7) | |
| No FH | 8 | 1.0 | 11 | 1.0 | 8 | 1.0 | 87 | 1.0 | 27 | 1.0 | |
| 1st⁰ FH of CVRF | 12 | 2.4 (0.6-10.7) | 11 | 1.1 (0.4-3.4) | 13 | 2.6 (0.6-11.5) | 109 | 1.4 (1.0-2.0) | 35 | 1.8 (0.8-3.7) | |
| No FH | 2 | 1.0 | 4 | 1.0 | 2 | 1.0 | 31 | 1.0 | 8 | 1.0 | |
| 1st⁰ FH of CVD or CVRF | 13 | 4.3 (0.6-32.3) | 11 | 0.9 (0.3-2.8) | 13 | 2.1 (0.5-9.3) | 117 | 1.7 (1.1-2.5) | 36 | 1.7 (0.8-3.7) | |
| No FH | 1 | 1.0 | 4 | 1.0 | 2 | 1.0 | 23 | 1.0 | 7 | 1.0 | |
CVD, cardiovascular disease; CVRF, cardiovascular risk factors; AD, atherosclerotic disease; MI, myocardial infarction; HF, heart failure; HTN, hypertension; FH, family history.
*
defined as MI or stroke occurring before age 55 in men and before age 65 in women