Table 5:

Multivariable risk association of first-degree family history with development of treatment-related hypertension among patients exposed to cardiotoxic therapy^*

	N	RR	95% CI	P value
1st⁰ FH of Hypertension	194	1.55	1.26-1.92	<0.0001
No FH of same outcome	55	1.00
1st⁰ FH of CVD	105	1.30	1.06-1.59	0.0103
No FH of CVD	144	1.00
1st⁰ FH of CVRF	205	1.58	1.24-2.01	0.0002
No FH of CVRF	44	1.00
1st⁰ FH of CVD or CVRF	217	1.71	1.27-2.28	0.0003
No FH of CVD or CVRF	32	1.00

FH, family history; CVD, cardiovascular disease; CVRF, cardiovascular risk factor

^*adjusted for sex, race/ethnicity, current age, combined variable of anthracycline dose and radiotherapy exposure