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Examples of important endogenous resistance mechanisms in methicillin-resistant Staphylococcus aureus (MRSA). Reproduced with permission, from [9]. (a) Active efflux mechanisms; (b) decreases in the permeability of the outer membrane of MRSA to drugs; (c) and enzymatic degradation of drugs by MRSA. All three mechanisms are responsible for the development of antibiotic drug resistance in MRSA.
