Table 1.
Schematic presentation of the 10q25.2-q26.3 region and gene positioning from top to bottom, with clinical features.
| Genes of interest on Chromosome 10 (q26.1-26.3) | ||
|---|---|---|
| Genes | Functions | References |
| PAX2 | Chronic kidney diseases | Deng et al; 2019. Ref.50 |
| EMX2 | Transcription Factor | Cecchi et al; 2002. Ref.31 |
| GLRX3 | Vesicoureteric reflux | Darlow et al; 2017. Ref.41 |
| EBF3 | Facial dysmorphisms; ID candidate | Lopes et al; 2017. Ref.131 |
| MGMT | Glioblastomas biomarkers | Jovcevska; 2019. Ref.105 |
| MDR1 | Amplified in glioblastomas | Suzuki et al; 2004. Ref. 193 |
| ADAM12 | Cancer; arthritis; cardiac hypertrophy | Ray et al; 2011. Ref.177 |
| DOCK1 | Cranio facial dysmorphism; ID candidate | Yatsenko et al; 2009. Ref.221 |
| TXNL2 | Breast, colorectal cancers | Qu et al; 2011. Ref.167 |
| FGFR2 | Microcephaly; ID candidate | Sangu et al; 2016. Ref.185 |
| PTPRE | Obesity-induced disease development | Kogelman et al; 2016 Ref.112 |
| MK167 | Cancer risk factor | Joensuu et al; 2004 Ref.104 |
| TCERG1 | Apoptotic agent; spliceosome | Montes et al; 2015 Ref.148 |
| BNIP3 | Mitophagy; cancer | Panigrahi et al; 2019 Ref.159 |
| JAKMIP3 | Candidate for COPD | Mostafaei et al; 2018 Ref.150 |
| DPYSL4/CRMP3 | Dendrite maintenance; AD, ID candidate | Quach et al; 2020 Ref.174 |
| LRRC27 | Intra-ocular pressure; glaucoma | Woo Kim et al; 2020 Ref.216 |
| PWWP2B | Histone modifications regulation | Zhang et al; 2018 Ref.225 |
| NKX6-2 | Hypomyelination; spastic ataxia | Chelban et al; 2020 Ref.27 |
| GPR123 | Candidate gene for asthma | Tremblay et al; 2008 Ref. 200 |
| VENTX | Putative tumor suppressor | Gao et al; 2016 Ref.67 |
| MIR202 | Reduced pancreatic tumor | Mody et al; 2017 Ref.146 |
| ADAM8 | Neuro-inflammation; asthma | Knolle et al; 2009 Ref.111 |
| TUBGCP2 | Neuronal migration defect | Mitani et al; 2019 Ref.145 |
| CALY | Attention deficit hyperactivity disorders | Plaisancie et al; 2014 Ref.163 |
| PRAP | Developmental regulation during pregnancy | Duan et al; 1997 Ref. 57 |
| ECHS1 | Deafness; epilepsy; optic atrophy | Haack et al; 2015 Ref.81 |
| MTG1 | Cardiac hypertrophy; mitochondrial function | Xu et al; 2019 Ref.219 |
| SPRN | Influence in TSE susceptibility | Lampo et al; 2007 Ref.118 |
| CYP2E1 | Alcohol abuse/immune interactions | Ratna et al; 2017 Ref.176 |
| FRG2B | Neuro-endocrine tumors | Snezhkina et al; 2019 Ref.190 |
| UTF | Germ cell lineage development | Kasowitz et al; 2017 Ref.109 |
| PAOX | Over-expressed in myelofibrosis | Salati et al; 2016 Ref.183 |
| SYCE | Non-obstructive azoospermia | Maor-Sagie et al; 2015 Ref.134 |
| PPP2R2 | Mitochondrial fragmentation; autophagy | Fang et al; 2013 Ref. 62 |
| DRD1IP | Attention deficit/hyperactivity disorders | Laurin et al; 2007 Ref.121 |