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. 2021 Jan 20;11:573095. doi: 10.3389/fneur.2020.573095

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Copyright © 2021 Chen, Wang, Yu, Howard, French, Chen, Wen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The summary schematic figure. (A) The distribution of ACE2 in the choroid plexus of the lateral ventricle (LV), hippocampus (Hip), middle temporal gyrus (MTG), and central glial substance (CGS) in the human brain. Pictures are modified from the human brain atlas (http://atlas.brain-map.org/) of the Allen Brain Atlas. (B) Representative ACE2 expression in the olfactory bulb (OB), choroid plexus of the lateral ventricle (LV), hippocampus (Hip), substantia nigra (SN), and cerebellum in the mouse brain. (C) Three potential routes for SARS-CoV-2 entering the CSF and/or spreading around the brain. Another potential route for SARS-CoV-2 entering the CSF from the CGS is not listed because of limited information regarding this brain area.