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(A) Using molecular dynamics and biophysical methods, Li et al., proposed a three-step model for the interaction of BA-like antimicrobials with gram positive pathogens. Initially the xanthone-based BA is adsorbed in a U-shaped conformation but eventually adopts a highly disruptive transmembrane configuration. (B) Structures of xanthone-based BA antimicrobials. Reproduced from Li et al. (2015), Elsevier.
