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. 2021 Jan 20;8:604151. doi: 10.3389/fchem.2020.604151

Figure 18.

Figure 18

Structures of antitumor drugs, gemcitabine (A) and paclitaxel (B), where R binds to the proposed hydrophobic squalene backbone (C). These “bolaform” prodrugs were shown to form nanoassemblies with in vitro activity on human and murine cancel cell lines. Reproduced from Caron et al. (2014), Royal Society of Chemistry.