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. Author manuscript; available in PMC: 2021 Feb 3.
Published in final edited form as: J Chem Inf Model. 2020 Dec 23;61(1):400–407. doi: 10.1021/acs.jcim.0c01201

Figure 2. The overall structure of human renin and its substrate binding site.

Figure 2.

The X-ray crystal structure of human renin (PDB: 2ren14), with the flap (residues Thr80 to Gly90) and dyad (Asp38 and Asp226, in surface rendering) colored green and red, respectively. A zoomed-in view of the substrate binding site and flap region is shown. Residues discussed in the main text are labeled.