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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Exp Gerontol. 2020 Dec 24;145:111200. doi: 10.1016/j.exger.2020.111200

Figure 5.

Figure 5.

General overview of the stages of hematopoiesis that give rise to myeloid and lymphoid cells that can influence muscle regeneration. Hematopoietic stem cells that reside in the bone marrow enter either the myeloid or lymphoid cell lineage by differentiating to become either common myeloid progenitors (CMPs) or common lymphoid progenitors (CLPs). CLPs then further differentiate to enter either the B-cell or T-cell lineage. B-cells are not known to have any direct influences on adult myogenesis. T-cells then differentiate to become CD8+ or CD4+ T-cells, which have direct effects on muscle regeneration. CMPs differentiate to become granulocyte progenitors (GPs) or monocyte progenitors (MPs). MPs then further differentiate to monocytes and then become macrophages, which have the most prominent influence on muscle regeneration of all immune cell populations.