Table 1.

MACIE model predictions for highlighted SNPs with connections to inflammatory and immune processes.

	Noncoding and Synonymous Variants Model				Nonsynonymous Coding Variants Model
SNP	MACIE01a	MACIE10	MACIE00	MACIE11	MACIE01	MACIE10	MACIE00	MACIE11
rs72832596	0.99*	7.1 × 10−30	4.5 × 10−25	3.4 × 10−5	-	-	-	-
rs2239527	5.8 × 10−4	1.8 × 10−12	2.2 × 10−15	0.99*	-	-	-	-
rs3094604	1.3 × 10−11	9.2 × 10−7	0.99*	2.6 × 10−17	-	-	-	-
rs1800629	0.99*	4.4 × 10−14	1.1 × 10−11	8.6 × 10−3	-	-	-	-
rs1800628	2.7 × 10−10	2.9 × 10−7	0.99*	1.7 × 10−16	-	-	-	-
rs1049133	1.5 × 10−4	0.93	0.07	4.6 × 10−3	-	-	-	-
rs28372851	0.99*	1.9 × 10−10	1.5 × 10−6	1.8 × 10−4	-	-	-	-
rs707949	-	-	-	-	2.2 × 10−3	0.62	0.14	0.23
rs707962	-	-	-	-	0.01	0.09	0.88	0.02

MACIE01, probability of regulatory class only (noncoding and synonymous variants model) or probability of damaging protein class only (nonsynonymous coding variants model); MACIE10, probability of evolutionarily conserved class only; MACIE00, probability of neither class; MACIE11, probability of both evolutionarily conserved class and regulatory class (Noncoding and Synonymous Variants Model) or probability of both evolutionarily conserved class and damaging protein class (Nonsynonymous Coding Variants Model). See Materials and Methods for more details on models and classes.

^aProbabilities in MACIE classes that would be normally rounded to 1 are written as 0.99 and denoted with an asterisk to reduce confusion, as the sum of all four classes for a single SNP must sum to 1.