Table 5.

Progression to inflammatory arthritis (IA) since aAb+ screening visit (n=131)

Model	Variable	HR (95% CI)	P-value	Integrated Time-Dependent AUC
Model 1a	Anti-CCP+ ≥ 2x cut-off at screening	4.09 (1.67-10.04)	0.002	0.66
*Model 1b	Anti-CCP+ ≥ optimal cut-off at screening	3.95 (1.57-9.91)	0.003	0.67
Model 2	Anti-CCP+ ≥ optimal cut-off at screening	3.52 (1.37-9.03)	0.01	0.70
	Race (NHW)	0.53 (0.21-1.36)	0.18
Model 3	Anti-CCP+ ≥ optimal cut-off at screening	3.23 (1.13-9.23)	0.03	0.73
	Race (NHW)	0.48 (0.16-1.40)	0.18
	Tender joint on exam (yes)	1.61 (0.59-4.42)	0.37

^*The optimal cut-off was calculated as ≥5 U/mL for anti-CCP2 (the same as the standard cut-off), and ≥30 U/mL for anti-CCP3.1

Differences in Uno’s C-statistic

Model 1b v. Model 2: p=0.21 Model 2 v. Model 3: p=0.45