Table 1.
Group Baseline Characteristics
| CN (n=372) | Obj-SCD (n=40) | PD-MCI (n=71) | F/KW | p | |
|---|---|---|---|---|---|
| Mean Age (SD) | 61.0 (10) | 60.1 (10) | 61.8 (8) | 0.19 | 0.824 |
| Mean Education (SD) | 15.7 (3) | 15.3 (3) | 14.9 (4) | 2.28 | 0.104 |
| % Male | 62% | 78% | 79% | 10.69a,b | 0.005 |
| % Caucasian | 96% | 98% | 90% | 5.71 | 0.058 |
| Mean UPDRS Motor (SD) | 19.5 (9) | 19.5 (10) | 23.0 (9) | 4.50a | 0.012 |
| Mean ADL (SD) | 93.4 (6) | 94.8 (5) | 92.6 (6) | 1.69 | 0.185 |
| Mean MOCA (SD) | 27.5 (2) | 26.4 (2) | 25.9 (3) | 17.28a,b | <0.001 |
| Mean HVLT Immediate Recall (SD) | 0.06 (.78) | −0.43 (1) | −1.1 (.77) | 70.22a,b,c | <0.001 |
| Mean HVLT Delay Recall (SD) | −0.02 (.71) | −0.2 (1.5) | −1.1(1) | 43.42a,c | <0.001 |
| Mean JOLO (SD) | 0.16 (.86) | 0.28 (.97) | −0.3 (1) | 7.54a,c | .001 |
| Mean LNS (SD) | 0.10 (.79) | 0.17 (.96) | −0.72 (.97) | 29.96a,c | <0.001 |
| Mean Animal Fluency (SD) | −0.04 (.85) | −0.05 (.96) | −0.73 (.94) | 19.12a,c | <0.001 |
| Mean SDMT (SD) | −0.04 (.77) | −0.34 (.85) | −0.79 (.97) | 26.57a,b,c | <0.001 |
| Mean IIV (SD) | .87 (.27) | 1.39 (.31) | 1.25 (.41) | 92.69a,b,c | <0.001 |
| Mean HVLT Learning Slope (SD) | 3.5 (1.4) | 2.2 (2) | 3.2 (1) | 15.20b,c | <0.001 |
| Mean HVLT FP (SD) | 1.2 (2) | 3.6 (4.6) | 2.9 (3) | 29.47a,b | <0.001 |
Standard deviations are listed in parentheses. Normative z-scores are presented for cognitive tests. KW = Kruskal Wallis H-Test; CI = Cognitively Normal; Obj-SCD = Objectively Defined Subtle Cognitive Decline; PD-MCI= Parkinson’s Disease Mild Cognitive Impairment; UPDRS Motor= Unified Parkinson’s Disease Rating Scale- part III; HVLT = Hopkins Verbal Learning Test; JOLO = Judgement of Line Orientation; SDMT = Symbol Digit Modalities Test; MOCA = Montreal Cognitive Assessment; ADL = Schwab & England Activities of Daily Living Scale; IIV = intra-individual variability; FP = False Positives;
CN group significantly different from PD-MCI;
CN group significantly different from Obj-SCD;
Obj-SCD group significantly different from PD-MCI