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. 2021 Jan 20;10:571384. doi: 10.3389/fonc.2020.571384

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Copyright © 2021 Xiao, He, Guo, He, Yang, Huang, Pan and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RHPN2 is required for cell growth and in vitro invasion of lung cancer cells. (A, B) the clonogenic formation assay was performed to detect the growth of A549 and H1299 cells stably expressing shControl and shRHPN2. The representative images and quantitative results were shown in (A, B), respectively. (C, D) Transwell invasion assay was used to examine invasive ability of A549 and H1299 cells. The representative images and quantitative results of invaded cells in A549 and H1299 cells were shown in (C, D), respectively. (E, F) the reduced expression of RHPN2 in RHPN2-depleted A549 and H1299 cells was confirmed by immunoblotting (E) and RT-qPCR (F). The data were representative of three independent experiments and were expressed as mean ± SD. **p < 0.01 and ***p < 0.0001 compared with control group.