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. 2021 Jan 20;10:571384. doi: 10.3389/fonc.2020.571384

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Copyright © 2021 Xiao, He, Guo, He, Yang, Huang, Pan and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RHPN2 upregulates GLUL expression and confers sensitivity to glutamine deprivation. (A) MTT assay to assess the proliferation of A549 cells stably expressing FLAG-RHPN2 or Vector control in the presence or absence of glutamine. (B) RT-qPCR analysis of expression of GLUL in A549 cells stably expressing RHPN2 or vector control. (C) Immunobloting analysis of cell lysates from A549 and H1299 cells stably expressing RHPN2 or vector control. (D) MTT assay to assess the proliferation of A549 cells stably expressing FLAG-GLUL or Vector control in the presence or absence of glutamine. (E) Quantitative results of tumorsphere number and size of H1299 cells expressing GLUL or vector control. (F) Kaplan-Meier overall survival curves for the patients with lung adenocarcinoma with different levels of glutamine synthetase (GS). **p < 0.01 and ***p < 0.0001 compared with empty vector.