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. 2021 Jan 20;10:586292. doi: 10.3389/fonc.2020.586292

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Copyright © 2021 Zormpas-Petridis, Noguera, Ivankovic, Roxanis, Jamin and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–F) Representative examples of the results obtained from the application of the SuperHistopath pipeline in whole-slide images of tumors (5x) of the Cancer Genome Atlas (TCGA) melanoma dataset [(G) Magnified regions of interest]. Note the important clinically-relevant phenotypes characterized by clusters of lymphocytes infiltrating the tumor in samples (B, D). or the majority of clusters of lymphocytes residing just outside the tumor area (left and central part) with only a few clusters infiltrating the tumor (right part) in sample (C).