Table 5.
Expression of cell cycle proteins p16, p53, and pRb in virus positive and negative tumors.
| Cell cycle protein | Virus positive | Virus negative | p-value | HPV-positive | HPV-negative | p-value | EBV-positive | EBV-negative | p-value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | |||||
| p16 | Overexpression | 12 | (80) | 3 | (2.9) | <0.001 | 12 | (100) | 3 | (2.8) | <0.001 | 0 | (0) | 15 | (13) | 1.0 |
| No overexpression | 3 | (20) | 101 | (97) | 0 | (0) | 104 | (97) | 3 | (100) | 101 | (87) | ||||
| p53 | Mutant-type overexpression | 2 | (13) | 51 | (49) | 0.002 | 0 | (0) | 53 | (50) | <0.001 | 2 | (67) | 51 | (44) | 0.80 |
| Wild-type | 11 | (73) | 28 | (27) | 10 | (83) | 29 | (27) | 1 | (33) | 38 | (33) | ||||
| 0-mutant type | 2 | (13) | 25 | (24) | 2 | (17) | 25 | (23) | 0 | (0) | 27 | (23) | ||||
| pRb | Positive (preserved expression) | 5 | (33) | 84 | (81) | <0.001 | 2 | (17) | 87 | (81) | <0.001 | 3 | (100) | 86 | (74) | 0.57 |
| Loss | 10 | (67) | 20 | (19) | 10 | (83) | 20 | (19) | 0 | (0) | 30 | (26) | ||||
HPV, human papillomavirus; EBV, Epstein–Barr virus.