Figure 5.

Tumor infiltrating lymphocyte (TIL) subset analyses: A. i) Scatter plots depicting associations between log-transformed CD3⁺ cells/mm² TILs and CD4⁺FOXP3⁻ cells/mm², ii) CD3⁺ cells/mm² and CD8⁺cells/mm², as well as iii) CD3⁺ cells/mm² and CD4⁺FOXP3+cells/mm².

B. Box and whisker plots representing intratumoral infiltrate density as log10-transformed CD4⁺FOXP3⁻ cells/mm² (i), CD8⁺cells/mm² (ii), CD4⁺ FOXP3⁺cells/mm² (iii) in CDK12 biallelic (red), monoallelic (yellow), and control cases (blue); iv) Tumor CD4⁺FOXP3⁻/CD8⁺ ratio between biallelic cases (red) and controls (blue).