Table 1.
Patients Characteristics.
| Overall | control | monoallelic | biallelic | p | |
|---|---|---|---|---|---|
| n | 180 | 144 | 8 | 28 | |
| Age at diagnosis (median [IQR]) | 61.0 [56.0, 64.2] | 61.0 [55.8, 64.0] | 59.0 [55.0, 63.5] | 62.5 [60.0, 65.0] | 0.4011 |
| T group (%) | 0.2812 | ||||
| T1 | 2 (1.1) | 1 (0.7) | 1 (12.5) | 0 (0.0) | |
| T2 | 20 (11.1) | 18 (12.5) | 0 (0.0) | 2 (7.1) | |
| T3 | 76 (42.2) | 57 (39.6) | 4 (50.0) | 15 (53.6) | |
| T4 | 34 (18.9) | 26 (18.1) | 2 (25.0) | 6 (21.4) | |
| TX | 48 (26.7) | 42 (29.2) | 1 (12.5) | 5 (17.9) | |
| T3/4 = Yes (%) | 110 (83.3) | 83 (81.4) | 6 (85.7) | 21 (91.3) | 0.6232 |
| N (%) | 0.1972 | ||||
| N0 | 42 (36.8) | 28 (33.3) | 5 (83.3) | 9 (37.5) | |
| N1 | 65 (57.0) | 51 (60.7) | 1 (16.7) | 13 (54.2) | |
| N2 | 7 (6.1) | 5 (6.0) | 0 (0.0) | 2 (8.3) | |
| N1/2 = Yes (%) | 72 (63.2) | 56 (66.7) | 1 (16.7) | 15 (62.5) | 0.0592 |
| M = M1 (%) | 96 (56.5) | 76 (56.3) | 2 (28.6) | 18 (64.3) | 0.2312 |
| Total Gleason score (G) (median [IQR]) | 9.0 [7.0, 9.0] | 8.0 [7.0, 9.0] | 9.0 [7.8, 9.0] | 9.0 [9.0, 9.0] | <0.0011 |
| G≤7vs G>8 = Yes (%) | 117 (72.2) | 84 (66.1) | 6 (75.0) | 27 (100.0) | <0.0012 |
| PSA at diagnosis (median [IQR]) | 63.0 [15.4, 176.1] | 53.5 [10.9, 162.0] | 106.0 [34.5, 137.0] | 72.0 [25.5, 229.2] | 0.4491 |
| Prostatectomy Y/N = Yes (%) | 22 (12.2) | 18 (12.5) | 2 (25.0) | 2 (7.1) | 0.3182 |
| Radiotherapy Y/N = Yes (%) | 67 (37.2) | 57 (39.6) | 2 (25.0) | 8 (28.6) | 0.4502 |
IQR= interquartile range; N= presence of nodal disease; M= presence of metastatic disease; PSA= prostate specific antigen.
1=
Kruskal-Wallis test.
2=
Fisher Exact test.