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. Author manuscript; available in PMC: 2021 May 30.
Published in final edited form as: Nat Chem Biol. 2020 Nov 30;17(2):213–221. doi: 10.1038/s41589-020-00656-8

Figure 1. Nikkomycin and polyoxin pathways.

Figure 1.

a. Overview of PN biosynthetic pathways. Steps shown in dashed arrows represent previous proposals that are revised in this study. Nucleobase (R) may be uracil (Ur), 5-methyluracil, 5-hydroxymethyluracil, or 5-carboxyuracil for polyoxins, and uracil, 5-methyluracil, imidazolone, or pseudouracil for nikkomycins. b. Revised mechanism of nikkomycin Z biosynthesis. The enzyme responsible for dephosphorylating nikkomycin Z 2’-phosphate has not been identified.