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. Author manuscript; available in PMC: 2021 May 30.
Published in final edited form as: Nat Chem Biol. 2020 Nov 30;17(2):213–221. doi: 10.1038/s41589-020-00656-8

Extended Data Fig. 7. Stereochemistry of AHOAP.

Extended Data Fig. 7

Coupling constants for possible stereochemistry of the 5’-amino, 6’-hydroxyl, 7’ carboxylic acid groups. Experimental evidence of JH4’-H5’ = 3.5 Hz, JH5’-H6’ = 10.5 Hz and JH6’-H7’ = 5.6 Hz for AHOA is most consistent with the stereochemistry of 4’-S, 5’-S, 6’-S, 7’-R indicating that AHOA and AHOAP have 4’-S, 5’-S, 6’-S, 7’-R stereochemistry. Dihedral angles were calculated with ChemDraw Professional v19.0 and ChemDraw 3D v19.0 (PerkinElmer Informatics).