Table 2.
Pathways enriched among the genes encoding the 26 all invasive epithelial ovarian cancer risk-associated circulating protein biomarkers identified.
| Pathwaya | Overlapb | P-value | Adjusted Pc | Genesd |
|---|---|---|---|---|
| Pathways Regulating Hippo Signaling WP4540 | 4/98 | 7.5 × 10−6 | 0.004 | INSR; KDR; MET; IGF1R |
| Hippo-Merlin Signaling Dysregulation WP4541 | 4/120 | 1.7 × 10−5 | 0.004 | INSR; KDR; MET; IGF1R |
| Focal Adhesion-PI3K-Akt-mTOR-signaling pathway WP3932 | 5/303 | 3.9 × 10−5 | 0.006 | INSR; IL3RA; KDR; MET; IGF1R |
| PI3K-Akt Signaling Pathway WP4172 | 5/340 | 6.8 × 10−5 | 0.008 | INSR; IL3RA; KDR; MET; IGF1R |
| Ras Signaling WP4223 | 4/184 | 8.9 × 10−5 | 0.008 | INSR; KDR; MET; IGF1R |
| Ebola Virus Pathway on Flost WP4217 | 3/129 | 6.1 × 10−4 | 0.041 | CD209; ICAM2; IGF1R |
| Canonical and Non-canonical Notch signaling WP3845 | 2/27 | 5.6 × 10−4 | 0.044 | MFAP2; DLK1 |
a
From the “WikiPathways 2019 Fluman” pathway database (with associated WP identifier number).
b
The number of genes out of the 26 genes evaluated/the total number of genes annotated to the pathway.
c
Adjusted for testing 472 pathways.
d
The genes (out of the 26 genes evaluated) that are annotated to the pathway.